PhenoCode Discovery Human Neurobiology Panel
The only ready-to-use panel enabling spatial proteomics for neuroscience research
Ultrahigh-plex Proteomics Reveal Brain Cell Phenotypes and Disease Pathology in Spatial Context
Normal
Alzheimer’s disease
Glioblastoma
Multiplex images of normal, Alzheimer’s disease (AD), and glioblastoma (GBM) samples showing the expression of seven markers.
- Olig2
- Iba1
- MAP2
- Synaptophysin
- Neurofilament-L
- GFAP
- MBP
Olig2
Iba1
MAP2
Synaptophysin
Neurofilament-L
GFAP
MBP
Normal
Alzheimer’s disease
Glioblastoma
Empowering Translational Neuroscience at the Cellular Level
Whether investigating neurodegenerative disease, neuroinflammation, or neuroplasticity, the PhenoCode™ Discovery Human Neurobiology Panel empowers you to understand key molecular and cellular interactions in the brain spatially – insights that traditional methods can’t deliver.
Cellular characterization
Identify and distinguish neuronal subtypes, glial cells, and vascular components with a well-defined set of 42 biomarkers.
Disease-specific insights
Detect neurodegenerative protein aggregates associated with Alzheimer’s disease and Parkinson’s disease, track inflammation-driven pathology, and assess blood-brain barrier integrity disruptions.
High-impact
data
Use an optimized, ready-to-use panel to spatially phenotype human brain formalin-fixed paraffin-embedded tissues.
Visualize the Complex Cells, Structures, and Interactions of the Brain
Neurons
- Neurofilament-L
- MAP2
- NeuN
- SMA
- DAPI
Astroglia
- GFAP
- AQP4
- Vimentin
- S100B
Microglia
- S100B
- Iba1
- Vimentin
- CD74
Neurons and Glia
- GFAP
- Iba1
- MAP2
- NeuN
- Vimentin
- S100B
Case Studies Highlighting Spatial Proteomics to Study the Brain
Understanding the Brain: Advancing Neurodegeneration Research with Ultrahigh-Plex Spatial Proteomics
Ritu Mihani, PhD
Director of Marketing, Akoya Biosciences
Applying spatial biology to neuroscience research presents unique challenges due to limited tissue availability and the fragile nature of brain tissue.
Learn how ultrahigh-plex spatial phenotyping has been applied to neurodegenerative disease research.
Decoding Neurodegeneration: High-plex Spatial Proteomics Reveal Distinct Cell Phenotypes and Pathological Signatures in Parkinson’s and Alzheimer’s Diseases
Dr. Birgitt Schuele
Associate Professor (Research) of Pathology at Stanford University
Dr. Birgitt Schuele showcases how ultrahigh-plex spatial proteomics is being used to uncover distinct cell phenotypes and pathological signatures in brain tissue.
Learn how spatial biology is advancing our understanding of neurodegeneration and enabling new insights into disease progression.
Resolve Cellular and Molecular Brain Interactions Using an Ultrahigh-plex Neuroscience Panel Designed for the PhenoCycler®-Fusion
Fast
Designed for the fastest spatial biology solution
Optimized
Ultrahigh-plex, ready-to-use panel for easy implementation
Customizable
Add additional markers using custom barcodes
Scale Up Your Neuroscience Insights with the Human Neuribiology Panel
A Simplified End-to-end Workflow for Ultrahigh-Plex Spatial Phenotyping
Stain
PhenoCode Discovery Human Neuro Panel
- Fully optimized
- 42-plex for deep insights
- Based on molecular barcoding chemistry — scalable, gentle & straightforward
Image
Automated Cycling and Imaging
- Iterative cycling with high-speed imaging
- Rapid fluidics, isothermal cycling for tissue integrity
- Multi-slide automation with parallel processing
Analyze
Image Analysis
- Manageable high-res data files
- Seamless multimodal data integration
- Compatible with all major analysis solutions
Integrate
Multimodal Phenotyping
- Fully compatible with major assay types for diverse analytes, including RNA, DNA and more